This resource has been compiled using a variety of sources. It includes references to the NICE guidance on eating disorders and a section on reference material contains links to material for professionals and patient information sites.
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The term eating disorder is used to define a number of conditions, affecting adolescents and adults. Eating disorders cause significant morbidity and mortality, leading as they do to multiple medical problems associated with both the physical and psychological consequences. There are considerable social issues to be addressed in many cases as the family of the individual are a key part of the package of care.
They are broadly classified into:-
Eating disorders taken as a whole are a common condition. Anorexia nervosa affects about 1 in 250 females and about 1 in 2000 males. Whilst most of these patients present in adolescence and early adulthood the condition is well recognised in later adulthood. Bulimia is far more common affecting up to 5 times as many individuals as anorexia. The numbers of sufferers of atypical eating disorders is not known; many patients do not come to medical attention but the numbers are thought to be greater than the numbers of sufferers of anorexia and bulimia combined.
The onset of an eating disorder is most commonly seen in adolescence. The impact on the physical development of the individual may be crucial in this growth phase, the impact on the educational and social development may also have far reaching consequences with many sufferers not reaching their full academic potential. Family life may be disrupted with further consequences for carers and siblings of sufferers. Patients with eating disorders often have depressed mood and are ambivalent to health care. Anorexia nervosa has the highest mortality rate for psychiatric illness in adolescence.
Access to appropriate healthcare is crucial. The services for patients with eating disorders vary across the country, early intervention appears to affect outcome however access to specialist services is not always possible locally. This patchy nature of services combined with the ambivalence of the sufferer may have negative consequences.
The outcome of an individual with anorexia nervosa is variable. Many sufferers do not access formal medical care and the prognosis in this group is unknown. A review of 68 studies published before 1989 showed that 43% recover completely, 36% improved, 20% develop a chronic eating disorder and 5% die from anorexia nervosa. The overall mortality in the studies varied from 0-21% from a combination of physical causes and suicide. An individual with bulimia has about a 50% chance of full recovery with 20% experiencing ongoing bulimia with a further 30% experiencing some symptoms but below the diagnostic threshold. Atypical eating disorders may have a higher remission rate than either anorexia or bulimia, however long-term studies are lacking in this condition.
In the UK the average GP will only have one or two patients who suffer with anorexia nervosa. The prevalence of eating disorders in young women may be as high as 5%. Patients with eating disorders consult more frequently than the norm prior to their diagnosis; this gives a window of opportunity to the GP. The very nature of anorexia increases the diagnostic difficulty for the GP; the patient may be secretive, dismissive and have an ambivalence toward seeking health care.
It is impractical to screen the entire general practice population for eating disorders, however high-risk groups can be targeted using a simple validated questionnaire. An example of this is the SCOFF tool, and automated version can be found by clicking here.
Opportunistic screening of high risk groups in general practice should include:-
There is evidence that early intervention improves outcomes and therefore screening is a valuable tool.
In order to establish a diagnosis of anorexia nervosa either the classification suggested by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) or by the World Health Organization's International Statistical Classification of Diseases and Related Health Problems (ICD) should be used.
There is no biochemical or haematological test for anorexia nervosa, however every case that is suspected should have a diagnostic work to exclude other causes of weight loss and to check for biological parameters that may be affected by the illness itself. The diagnosis relies on a combination of exploring the beliefs of the patient, the experience of the patient and others and the physical characteristics exhibited by the patient. Notably, diagnostic criteria are intended to assist clinicians, and are not intended to be representative of what an individual sufferer feels or experiences in living with the illness.
The diagnostic criteria used in the DSM-IV-TR are:-
Furthermore, the DSM-IV-TR specifies two subtypes:
The ICD-10 criteria are similar, but in addition, specifically mention
If onset is before puberty, that development is delayed or arrested.
Anorexia nervosa particularly in its early stage may be difficult to spot both for healthcare professionals and for close members of the family. Once established the physical, psychological and social effects of the condition may lead to a number of conditions:
The primary care team may have the opportunity to screen high-risk groups and is also likely to be the first point of contact with the patient. Frequently initial contact was made by a worried relative or school teacher who has observed weight loss or specific food related behaviours such as skipping meals, hiding food or adopting a restricted diet. Indeed any of the physical, psychological or social behaviours listed. There is a danger that the inexperienced practitioner may make light of the symptoms or feel that they are self-inflicted. The history must be taken with a sympathetic ear and in an empathetic and non-judgemental manner. A careful history should be taken and matched against the diagnostic criteria. The mean age of onset is 16-17.
The NICE guidance lists the following factors to be considered
A physical examination is required to calculate the BMI (or use centile charts are aged less than 18) and pulse and blood pressure should be taken. In patient showing a degree of emaciation, core temperature, examination of the peripheries for circulation and oedema, a check for postural hypotension and a squat test to check muscle power should also be performed. The patient is asked to squat and then rise without using their arms. If the patient needs to use their arms the balance then this may indicate a moderate risk, if the patient needs to use their arms to leverage themselves up in this is an indication of profound muscle weakness and high risk.
Full blood count, ESR, U+E, Creatinine, liver function tests, random blood glucose and urinalysis would screen for most of the common differential diagnoses. An ECG may be appropriate particularly if there is bradycardia, electrolyte imbalance or a BMI of less than 15. In more severe cases calcium, magnesium, phosphate, serum proteins and creatinine kinase may also be required. In the differential diagnosis of amenorrhoea with weight loss thyroid function, follicle stimulator hormone, luteinising hormone, prolactin and a chest x-ray should be performed.
A DXA scan may be required to identify bone loss in chronic cases or in cases with prolonged amenorrhoea.
The Royal College of psychiatrists has produced an algorithm for the initial diagnosis and management of suspected cases of eating disorder - click here for more.
When considering the management and treatment of anorexia nervosa a multi-professional strategy must be adopted. The individual may require physical therapy for complications of their eating disorder, psychological therapies such as CBT, psychopharmacological intervention for associated depressive symptoms and family therapy to repair damage to relationships. There may also be issues around supporting the carer and certainly there are information needs in close family members or carers in different contexts. Central to interventions is obviously the patient, the consent to involvement of others is vital; however with the inherent ambivalence and risk of denial of the problem, the healthcare professionals need to tread carefully.
In children and adolescents family therapy tends to be a key intervention. There is however a poor evidence base to this, and indeed, other interventions in this condition. The availability of specialist child and adolescent services is variable, however if available family interventions dealing with eating behaviour have some evidence base. Specialist services may offer cognitive behavioural therapy, psychodynamic psychotherapy, motivational enhancement therapy and other family interventions.
The initial aim of psychological intervention must be to engage the patient in that intervention. The denial of a problem and the ambivalence to health care exhibited in this condition is a barrier that must be overcome before psychological intervention can work. Healthcare professionals must build a relationship based on trust and empathy with the patient, their carers and their family as appropriate. There must be an ethos of collaboration with the patient and the patient needs to engage with the process in the same spirit. This engagement may wax and wane with time, the therapist must be sensitive to this, gaining small victories where possible.
In general the aim of the interventions are to promote healthy eating and weight gain, to reduce the impact of other eating disorder related psychological issues and in this way promote psychological recovery. In the context of the patient who has gained weight following a period of hospitalisation the aim of intervention is to maintain the weight gained. In the proportion of patients that go on to develop chronic anorexia nervosa the goals of treatment with psychological intervention may differ, and improvement in the quality of life and maintenance of a safe weight may be paramount.
The evidence base the psychological intervention is poor, family therapy in adolescence has some evidence to support its use, however other interventions show variable results.
No drug therapy has been shown to alter the course of anorexia nervosa unless there is co-morbid depression or OCD. Antidepressants and antipsychotics risked doing harm specifically by prolonging the QT interval, evidence of benefit is minimal.
Hospital admission is required when the weight or biochemical disturbances place the patient at risk. Detention under the mental health act is occasionally required and forced feeding is reserved as a last resort. Useful weight gains can be made in hospital and are supervised conditions and it also gives the
NICE recommends that the treatment of anorexia nervosa includes primary secondary and sometimes tertiary healthcare providers. A multidisciplinary approach is required and the Royal College of psychiatrists have produced an algorithm for diagnosis and initial management.
The role of the GP is therefore:-
Bulimia nervosa making a diagnosis
The diagnostic and statistical manual of mental disorders (DSM-IV TR) lists the criteria for diagnosing a patient with bulimia nervosa as:-
Two subtypes are identified:-
Purging - here the individual self induce vomiting either by triggering the gag reflex or ingesting emetics. This is an attempt to rapidly remove food from the body before it can be digested. Laxative, diuretics and enemas may also be used for the same reason.
Non-purging - less than 10% of sufferers of bulimia nervosa adopt excessive exercise or excessive fasting to offset the binge eating.
Bulimia nervosa is far more common than anorexia nervosa and up to 5 in 100 of young women (the mean age of onset is 18-19) attending their GP may have the condition. Patients with bulimia tend to have a body weight that is either just below, normal or just above average BMI. Many patients will not exhibit physical symptoms however excessive use of purging techniques can lead to dehydration, electrolyte imbalance and cardiac arrhythmias.
Although the binge eating and purging is normally performed in secret, patients with bulimia are often relieved to tell somebody else about it. When directly questioned many will answer truthfully, even in extreme cases of frequent bingeing and purging.
In most patients physical examination is entirely normal, as are biochemical and haematological parameters. Possible physical effects include:-
Mood disturbance is extremely common in bulimia nervosa with symptoms of anxiety being prominent. Low self esteem and self loathing, along with a feeling of disgust at themselves over the overeating and purging may be present. When compared to anorexics more bulimics will have clinical depression. Bulimia nervosa sometimes arises out of a pre-existing anorexic illness, where the patient has lost the control over restriction of eating manifesting itself in uncontrolled bingeing.
Some sufferers leave obvious clues about their problem such as leaving the wrappers from food for others to find and even bags of vomit left in prominent places. The binge eating episodes are usually planned, with food purchased in advance and prepared to be consumed in secret. An individual may also avoid situations where they are exposed to food in the presence of others. This tends to lead to further social isolation.
The primary care team are likely to have opportunities to diagnose patients with bulimia nervosa. Sufferers have a much higher consultation rate pre-diagnosis than the general population. Use of screening with the SCOFF questionnaire is appropriate. As with anorexia the first contact may be with worried family members, friends or schoolteachers. Risk factors for bulimia nervosa include:-
Other factors that may have a bearing include a history of sexual or physical abuse, pre-morbid psychiatric disorder (including anorexia) and disruptive events in childhood.
The diagnosis of bulimia nervosa mainly hinges on a good history as physical examination is likely to be normal however BMI should be measured, the BP should be taken both sitting and standing to check for postural hypotension. Laboratory investigations again are likely to be normal although urea, electrolytes and creatinine should always be measured.
The Royal College of psychiatrists has produced an algorithm for the initial diagnosis and management of suspected cases of eating disorder.
Uncomplicated bulimia nervosa can be treated in primary care (given access to appropriate support services), referral should be made if there is a lack of progress, the patient is pregnant or has a pre-existing condition such as diabetes.
General considerations about the patients health or mental wellbeing may also prompt referral as should suicidal tendencies. With the most effective treatments 50% of patients can be expected to be free of symptoms between two and 10 years after diagnosis. 20% of patients will develop chronic bulimia nervosa and the remaining 30% were either follow a relapsing and remitting course or develop chronic subclinical bulimic symptoms (other studies show even larger numbers in sustained remission – described in the NICE guideline).
Although long-term follow-up studies in this condition are few, it seems that untreated, the majority of bulimics will continue to be symptomatic for many years.
Cognitive behavioural therapy has strong evidence to support its use. A specific therapy has been developed for use in bulimia and it utilises three distinct but overlapping phases:-
A Clinical Evidence report on 34 randomised controlled trials of CBT showed a significant increase in the proportion of patients abstaining from a binge-purge cycle of 43% with only 5% in the control group abstaining.
The same review uncovered insufficient evidence to recommend any other form of psychotherapy. Guided self-help cognitive behavioural therapy conducted in the primary care setting was as good as specialist CBT in one randomised control trial.
The use of antidepressant medication in the treatment of bulimia has been studied in adults. There is no evidence base for the use in adolescents and they do not have a licence for use in this indication. In adolescents drug treatment should not therefore be a first line intervention.
In adults there is evidence for the efficacy of tricyclic antidepressants, irreversible monoaimine oxidase inhibitors (but not moclobamide) and to a lesser extent SSRIs.
There is also evidence that a combined approach of CBT and antidepressant use enhances the effect of CBT. Doses of antidepressants used in the trials are similar to those used to treat depression (with the exception of fluoxetine at 60mg daily).
It is thought that the use of irreversible monoaimine oxidase inhibitors may cause further problems, as the exclusion of tyramine from the diet may focus the patient further on food.
And when comparing a combined approach of antidepressants and CBT verses CBT alone NICE makes the following points:-
This classification of eating disorders is sometimes called eating disorders not otherwise specified (EDNOS – US classification) and includes binge eating disorder. This categorisation covers individuals that meet some but not all of the diagnostic criteria for anorexia nervosa or bulimia. Individuals in this category may shift to a different diagnostic entity, occasionally meeting all the diagnostic criteria for both anorexia nervosa and bulimia.
Examples include: -
In order to diagnose binge eating disorder the eating episodes are associated with three or more of the following:
Marked distress regarding binge eating is present and social avoidance is common.
Nice recommendation for a treatment strategy states:-
After completing this learning tool you may feel that you wish to incorporate some of the learning points in your own practice.
It is clear that anorexia nervosa is the most serious eating disorder however the numbers dealt with in general practice will be low.
The overall incidence of eating disorders in the young female population that presents to general practice is approximately 5%.
By raising awareness and being equipped to deal with these patients when they present access to appropriate treatment will be easier for your patients.
The term eating disorders covers a spectrum of conditions that are classified into:-
Anorexia nervosa carries a significant risk of morbidity and has the highest mortality rate for adolescent mental health conditions.
Patients with eating disorders are often secretive about their condition.
Initial presentation may be from a worried parent, friend or schoolteacher.
Primary care has a role to play in all eating disorders
Therapy for eating disorder may be multidisciplinary and multimodal. There is evidence for the use of psychotherapy (particularly CBT-BN) and pharmacotherapy (notably antidepressants)
Many patients who have eating disorder are unidentified
Young females are at highest risk although young males with the condition may remain undiagnosed
Patients with an eating disorder have a higher consultation rate than the general population in general practice
There is a validated screening tool (SCOFF) that consists of five simple questions
For professionals
Self help (CBT)
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